Comparison of zwitterionic N-alkylaminomethanesulfonic acids to related compounds in the Good buffer series

• Robert D. Long,
• Newton P. Hilliard Jr,
• Suneel A. Chhatre,
• Tatiana V. Timofeeva,
• Andrey A. Yakovenko,
• Daniel K. Dei and
• Enoch A. Mensah

Beilstein J. Org. Chem. 2010, 6, No. 31, doi:10.3762/bjoc.6.31

• unstable at elevated temperature (as when autoclaving) – thus limiting their utility. Keywords: aminomethanesulfonate buffers; Good buffer; morpholinomethanesulfonic acid; pKa comparison; zwitterion; Introduction Some of the most widely used biological buffers are the compounds based on tertiary and